Scientist - Immunology/Immuno-oncology
Our client is a well-funded, early stage biotech, which has identified novel tumour-specific antigens derived from reactivated endogenous retroviral sequences. The company is using this foundational discovery to enable the development of a range of pharmaceutical products including vaccines, biologics and cell therapies. Importantly, these pharmaceuticals are non-personalised and thus able to broadly impact the needs of oncology patients. They are looking to increase the capacity of their target validation pipeline to expand the number of tumour types, in which they can confirm the presence of antigenic peptides, predicted from transcripts arising due to dysregulated human endogenous retroelements.
They are looking for a highly motivated Scientist who has a deep passion for immunology and the role of T-cells in the exciting field of immuno-oncology. You will help the team to build an understanding of human T-cell biology against their novel tumour-specific antigens and translate this understanding into transformative products that enhance the response of CD8+ cells in the tumour microenvironment. As a member of the research team, you will collaborate with their internal team of scientists, including proteomic/mass spectrometry experts and report to the Associate Director for Immunology. This position represents an excellent opportunity for someone to discover and develop an early stage product through to clinical application.
- You will be responsible for designing, conducting and evaluating experiments to establish the role of novel antigens in driving T-cell biology, including T-cell profiling for very low frequency cells (use of Elispot, pentamers), FACS sorting/analysis, CTL cloning and recombinant T-cell receptor expression/characterization.
- Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses and on-the-job training.
- Ensuring accurate records of all work by completing electronic laboratory notebooks on time, following agreed procedures
- Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
- Operating in accordance with the Company's Health and Safety policies, especially within a laboratory environment.
- 10% of time- Assist the team with ordering of reagents, services and consumables. Generating purchase orders and obtaining quotes.
Experience and Knowledge:-
Essential - Experience of working in an Immunology/Cell biology laboratory setting,
OR a relevant PhD.
Desirable - Experience of core Immunology techniques including cell culture, Flow cytometry, Immunoassays, ELISPOT, CTL assays, microscopy.
Qualifications - BSc, MSc or PhD in Immunology, cell biology, biochemistry, molecular biology or related discipline
Based South East
Negotiable salary + benefits